IgG3 Subclass: a possible trigger of mixed cryoglobulin cascade in hepatitis C virus chronic infection

HCV is a hepatotropic and lymphotropic virus and is the most frequent cause of "benign" mono-oligoclonal B-lymphocyte proliferation, observed in mixed cryoglobulinemia (MC). The study aims to investigate the presence, prevalence and characteristics of the subclasses of cryoglobulins in HCV-patients to look for a relationship with MC. Fifty HCV-infected patients with cryoglobulins were enrolled. IgG subclasses were characterized in cryoprecipitate, and serum IgG and IgM Rheumatoid Factor (RF) were determined.

from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/2thgmvb
via IFTTT