The neural bases of ictal tachycardia in temporal lobe seizures

Temporal lobe epilepsy (TLE) can lead to intense changes in cardiac autonomic functions during both interictal and ictal periods (Lotufo et al., 2012; Eggleston et al., 2014). Tachycardia, defined as a decrease in the ECG R-R intervals (RR) (increase in heart rate), is the most common cardiac change occurring during epileptic seizures (Opherk and Hirsch, 2002; O'Regan and Brown, 2005; Toth et al., 2010) whereas bradycardia occurs in only 2% of them (Moseley et al., 2010). Tachycardia was proposed as a biomarker providing a somatic indicator of temporal lobe (TL) seizure onset (Osorio, 2014; Schiecke et al., 2014; Osorio and Manly, 2014; Jeppesen et al., 2015; Osorio and Manly, 2015; Behbahani et al., 2016; Van de Vel et al., 2016), opening the way to automatized and noninvasive seizure detection and treatment delivery prior to, or at the onset of, a TL seizure.

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