Treatment and retreatment with omalizumab in chronic spontaneous urticaria: Real life experience with twenty-five patients

Publication date: Available online 26 May 2017
Source:Allergology International
Author(s): Murat Türk, İnsu Yılmaz, Sakine Nazik Bahçecioğlu
BackgroundPrevious data have shown the high efficacy of omalizumab in chronic spontaneous urticaria (CSU). However, factors that may be effective on the response to therapy, relapse rates after drug discontinuation, and efficacy of retreatment remain unclear. This study aimed to determine the efficacy of omalizumab in CSU refractory to conventional therapy, to identify possible factors affecting treatment response and relapse, and also to evaluate the efficacy of retreatment on relapsed disease.MethodsThe data of CSU patients treated with 300 mg/month omalizumab for at least 3 months were retrospectively analyzed. In order to evaluate the efficacy of treatment and retreatment, baseline and follow-up concomitant medication score (CMS) and urticaria activity score (UAS) were calculated. Possible factors affecting treatment response and relapse were identified.ResultsTwenty-five patients were included. The median duration of omalizumab therapy was 6 (6–12) months. Of the patients with baseline UAS 6 (5.5–6) and CMS 13 (10–15), 8 (32%) had complete response (UAS = 0) and 2 (8%) were non-responders after 3 months of therapy. None of the complete responders were positive for IgG-anti-TPO. After discontinuation of omalizumab therapy, 11 (61%) patients experienced relapse and 10 of them received retreatment with omalizumab. Half of the patients had complete response, and half had partial response (UAS = 1–4) after retreatment. No treatment related adverse events were documented.ConclusionsOmalizumab has high efficacy in both the treatment and retreatment of CSU; however, relapse rates after discontinuation are high. Autoimmune markers may be helpful in predicting treatment response and relapse.



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