The effect of bone mass and architecture on mandibular condyle after mandibular distraction

Publication date: Available online 25 May 2017
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Author(s): Daisuke Suda, Atsushi Ohazama, Takeyasu Maeda, Tadaharu Kobayashi
ObjectiveMandibular distraction surgery is a critical treatment for jaw deformity. However abnormal mandibular condylar bone resorption is often seen as complication after surgery. Our previous study using a rat mandibular distraction model has suggested that over loading leads to mandibular condylar resorption. Host factors are also believed to influence the resorption. To understand the relationship between host factor and the resorption, we investigated the effect of changing bone mass and architecture on mandibular condyle using FK506.Study DesignAn immunosuppressant drug – FK506 – was used to compromise bone mass and architecture in this study. Animals were divided into four groups; distraction surgery (Dist), FK506 administration (FK), distraction surgery with FK506 administration (FK+Dist) and neither surgery nor FK506 administration (Cont).ResultsThe FK group showed reduced bone mass and impaired bone architecture. The Dist group exhibited abnormal bone resorption on the surface of the condyles, which was slightly exacerbated in the FK+Dist group. Bone defect length decreased over time due to bone apposition in the Dist group. However, the FK+Dist group maintained the bone defect length.ConclusionsThese results suggest that bone mass and architecture strongly affect the tolerance to the overloading and adaptation with bone apposition in condylar resorption site.



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