Green tea EGCG enhances cardiac function restoration through expression of survival signaling in DM rats with autologous adipose tissue-derived stem cell

The present study tests a hypothesis that cardioprotective effects mediated by autologous adipose-derived stem cells (ADSC) in rats afflicted with insulin-dependent diabetes mellitus (IDDM), may be synergistically enhanced by oral treatment with green tea epigallocatechin gallat (ECCG). Wistar rats were divided into sham, DM, DM+ADSC (autologous transplanted 1x106 cells/rat) and DM+ADSC+E (E, green tea oral administration EGCG). Heart tissues were isolated for all rats and investigations were performed after 2-months treatment. In the groups of sham, DM and DM+ADSC, we can find that DM induces cardiac-dysfunction (sham and DM) and autologous transplantation of ADSC can partially recover cardiac functions (DM and DM+ADSC) in DM rats. Compared to DM+ADSC, significant improvement in cardiac-functions can be observed in DM+ADSC+E in echocardiographic data, histological observations and even in cellular protein expression. Oral administration of green tea EGCG and autologous transplantation of ADSC show synergistically beneficial effects on diabetic cardiacmyopathy in DM rats.

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