Pulmonary Vascular Function and Aerobic Exercise Capacityat Moderate Altitude.

Purpose: There has been suggestion that a greater "pulmonary vascular reserve" defined by a low pulmonary vascular resistance (PVR) and a high lung diffusing capacity (DL) allows for a superior aerobic exercise capacity. How pulmonary vascular reserve might affect exercise capacity at moderate altitude is not known. Methods: Thirty-eight healthy subjects underwent an exercise stress echocardiography of the pulmonary circulation, combined with measurements of DL for nitric oxide (NO) and carbon monoxide (CO) and a cardio-pulmonary exercise test at sea level and at the altitude of 2250m. Results: At rest, moderate altitude decreased arterial oxygen content (CaO2) from 19.1+/-1.6 to 18.4+/-1.7 ml/dl, p

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