Breaks in Sitting Time: Effects on Continuously Monitored Glucose and Blood Pressure.

Purpose: We examined the effects of interrupting prolonged sitting with multiple 2-min walking breaks or one 30-min continuous walking session on glucose control and ambulatory blood pressure (ABP). Methods: Ten overweight/obese, physically inactive participants (5 men; 32+/-5 y, BMI 30.3+/-4.6 kg[middle dot]m-2) participated in this randomized four-trial crossover study, with each trial performed on a separate, simulated workday lasting 9h: 1) 30 min of continuous walking at 71+/-4% HRmax (30min-MOD); 2) 21x2-min bouts of moderate-intensity walking at 53+/-5% HRmax (2min-MOD), each performed every 20 min (42 min total); 3) 8x2-min bouts of vigorous-intensity walking at 79+/-4% HRmax (2min-VIG), each performed every h (16 min total); 4) 9h of prolonged sitting (SIT). Participants underwent continuous interstitial glucose monitoring and ABP monitoring during and after the simulated workday spent in the laboratory, with primary data analysis from 12:30 h to 07:00 h the next morning. Results: Compared with SIT (5.6+/-1.1 mmol[middle dot]L-1), mean 18.7-h glucose was lower during the 2min-MOD (5.2+/-1.1 mmol[middle dot]L-1) and 2min-VIG (5.4+/-0.9 mmol[middle dot]L-1) trials and mean 18.7-h glucose during the 30min-MOD trial (5.1+/-0.8 mmol[middle dot]L-1) was lower than all other trials (P

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