Πέμπτη 18 Μαΐου 2017

Increased Left Ventricular Extracellular Volume and Enhanced Twist Function in Type 1 Diabetic Individuals

Individuals with type 1 diabetes (T1D) characteristically have high glycemic levels that over time can result in reactive fibrosis and abnormalities in myocardial function. T1 mapping with magnetic resonance imaging (MRI) can estimate the extent of reactive fibrosis by measurement of the extracellular volume fraction (ECV). The extent of alterations in the ECV and associated changes in left ventricular (LV) function and morphology in individuals with T1D is unknown. Fourteen individuals with long-term T1D and fourteen sex-, age-, and body mass index-matched controls without diabetes underwent MRI measurement of myocardial T1 and ECV values as well as LV function and morphology. Ventricular mass, volumes and global function (LVEF, circumferential/longitudinal/radial strain) were similar in those with T1D and controls. However, those with T1D had larger myocardial ECV (0.221±0.018 versus 0.201±0.021, P=0.008) and increased native (non-contrast) myocardial T1 values (1211±44ms versus 1172±43ms, P<0.001) as compared to controls. Both the ECV and native T1 values significantly correlated with several components of torsion and circumferential-longitudinal shear strain (Ecl, the shear strain component associated with twist). Individuals with T1D had increased systolic torsion (P=0.035), systolic torsion rate (P=0.032), peak Ecl (P=0.001) and rates of change of systolic (P=0.007) and diastolic (P=0.007) Ecl. Individuals with T1D, with normal structure, LVEF and strain, have increased extracellular volume and increased native T1 values with associated augmented torsion and Ecl. These measures may be useful in detecting the early stages of diabetic cardiomyopathy and warrant larger prospective studies.



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