Attenuated Error-Related Potentials in Amyotrophic Lateral Sclerosis with Executive Dysfunctions

Amyotrophic lateral sclerosis (ALS) is the most common form of motor neuron diseases. It is characterized by progressive degeneration of the upper and lower motor neuron, resulting in muscle paralysis and atrophy. Despite intensive research, curative therapy is still not available. The prognosis is fatal, with a median survival of 2-5 years after disease onset. The incidence in Europe is 2.16 per 100,000 (Logroscino et al., 2010). Different genetic mutations have been associated with the familial form of disease (Robberecht and Philips, 2013), but the etiology of the more common sporadic ALS (90% of cases) remains largely unknown.

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