Ocimum basilicum extract exhibits antidiabetic effects via inhibition of hepatic glucose mobilization and carbohydrate metabolizing enzymes

2017-01-03T01-56-20Z
Source: Journal of Intercultural Ethnopharmacology
Chinelo Ezeani, Ifeoma Ezenyi, Theophine Okoye, Charles Okoli.
Aim: Ocimum basilicum L (Lamiaceae) is used as traditional remedy for different ailments, including diabetes mellitus. This study investigated the antidiabetic effects of an extract of aerial parts of O. basilicum. Methods: Antihyperglycemic effect of the extract was determined by its effects on alpha amylase and alpha glucosidase in vitro, while antidiabetic properties were studied in alloxan-induced diabetic rats treated for 28 days with extract and compared to those treated with oral metformin (150 mg/kg). The study and analysis was conducted between 2014 and 2015. Results: Treatment with 100 and 200 mg/kg extract significantly (P

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