Ibuprofen before Exercise Does Not Prevent Cortical Bone Adaptations to Training.

Using a nonsteroidal anti-inflammatory drug (NSAID) before a single bout of mechanical loading can reduce bone formation response. It is unknown whether this translates to an attenuation of bone strength and structural adaptations to exercise training. PURPOSE: To determine whether NSAID use before exercise prevents increases in bone structure and strength in response to weight-bearing exercise. METHODS: Adult female Wistar rats (n=43) were randomized to Ibuprofen (IBU) or Vehicle (VEH) and Exercise (EX) or Sedentary (SED) groups in a 2x2 (drug, activity) ANCOVA design with body weight as the covariate, and data are reported as mean+/-SE. IBU drops (30 mg/kg BW) or VEH (volume equivalent) were administered orally 1 hour before the bout of exercise. Treadmill running occurred 5 days/week for 60 min/day at 20 m/min with a 5[degrees] incline for 12 weeks. MicroCT, mechanical testing, and finite element modeling were used to quantify bone characteristics. RESULTS: Drug*activity interactions were not significant. Exercise increased tibia cortical cross-sectional area (EX: 5.67+/-0.10; SED: 5.37+/-0.10 mm2, p

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