The Role of Capsaicin-Sensitive Nerves in Regulating Blood Dehydroepiandrosterone Sulfate Levels in Rats in Normal Conditions and in Metabolic Syndrome

The effects of stimulation of capsaicin-sensitive nerves (CSN, capsaicin 1 mg/kg, s.c.) and their deafferentation (capsaicin 150 mg/kg s.c.) on the blood dehydroepiandrosterone sulfate (DEAS) level in normal conditions and metabolic syndrome (MS) induced by consumption of fructose (12.5% solution, 10 weeks) were studied. The criterion for the development of MS was provided by data showing increased blood triglycerides, lipid peroxidation (LPO) products, and impaired glucose tolerance. Stimulation of CSN in rats with a normal diet led to an increased DEAS level, while deafferentation decreased the blood level of this hormone. The fructose diet decreased the DEAS level, induced triglyceridemia, increased LPO, and impaired glucose tolerance. The decreased blood DEAS concentration seen after consumption of fructose was eliminated by stimulation of CSN, with simultaneous reductions in indicators of metabolic syndrome. Preliminary deafferentation of CSN in fructose-consuming rats blocked the stimulation-induced restoration of DEAS. The authors suggest that CSN are involved in the mechanisms controlling the blood DEAS content in normal conditions and metabolic syndrome.

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