Role of Endothelial Cell Function Assessment Using Flow-mediated Dilation for Diagnosing Coronary Artery Disease in Low-risk Patients

2016-10-21T17-13-47Z
Source: Acta Informatica Medica
Seyed Mahmoud Nouraei, Ali Ghaemian,Hanieh Shiraj,Reza Ali Mohammadpour, and Alireza Malekrah.
Introduction: Flow-mediated dilation (FMD) measurement in the brachial artery (BA) is a method of endothelial cell function assessment. We can use it to predict atherosclerotic coronary artery disease. We investigated the predictive value of FMD for the presence of coronary artery disease (CAD) in a low-risk population of patients without major (CAD) risk factors. Materials and Methods: Three hundred and ninety-seven patients (age 53.2±9 years; 194 men) with chest pain admitted for coronary angiography were enrolled in this study. FMD was measured in the BA before coronary angiography using high-resolution ultrasound. Results: Coronary angiography was normal in (151)patient, (149) with single and (97) multi-vessel disease. FMD was significantly higher in normal coronary groupagainst patients with coronary artery disease (11.1±2.6% vs. 6.8±3.1%; P


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