Isolated hypoganglionosis in young man with autism

A 30-year-old autistic man, presented recurrent sub-occlusive episodes since five years. The CT-scan suggested a bowel obstruction due to volvulus of sigmoid colon with a marked gaseous distention of the right colon inducing liver dislocation on the left and vena cava compression (Fig. 1). A colonoscopy was performed to derotate the volvulus. However, for the appearance of megacolon up to a diameter of 16cm, a total colectomy was performed. Histological examination showed a framework of intestinal hypoganglionosis (Fig.

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