Distinguishing spinocerebellar ataxia with pure cerebellar manifestation from multiple system atrophy (MSA-C) through saccade profiles

Motor coordination is achieved by the cerebellum, which sets the amplitude of the initial pulse that causes a movement, predicting the correct moment through an internal model to excite agonists and antagonists to start and stop the limb at the desired location and avoid overshoot, thereby enabling elements of coordinated and smooth actions and even integrating these into a complex action (Itoh, 2010). In order to induce coordinated motor actions, the cerebellar output acts as accelerator and brake to give the movement the appropriate speed and to stop it at the appropriate time.

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