Nature Reviews Genetics 17, 377 (2016). doi:10.1038/nrg.2016.74
Author: Darren J. Burgess
Regulatory elements — particularly transcriptional promoters and enhancers — typically consist of multiple binding sites for transcription factors (TFs) and are often detected and interpreted based on the occurrence of consensus, high-affinity binding motifs for TFs. A new study highlights that, beyond TF binding affinity,
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