Alexandros Sfakianakis
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182
6948891480
Δευτέρα 8 Μαΐου 2017
I strongly recommend that all practicing physicians consider such a list, and review it occasionally. I wish for the judgement to know what is best for my patients and to weigh the merits of interventions; surgically, medically, and radiotherapeutically. I wish that I can master the complexities of the practice of medicine and be worthwhile as a physician. I wish for the honesty and integrity to objectively assess my competencies and fallibilities. I wish for the intellectual drive to maintain currency of knowledge. I wish for the wisdom to assess and maintain appropriate costs for medical care. I wish for the integrity to avoid marketing my skills and accomplishments unrealistically and erroneously. I wish for the compassion that allows me to separate my personal problems from the needs of the patients that I serve. I wish for the courage to challenge the wisdom of those that create policies and regulations that fail to consider the full dimension and scope of medical care. Please p
The adaptor protein ARA55 and the nuclear kinase HIPK1 assist c-Myb in recruiting p300 to chromatin
Publication date: Available online 8 May 2017
Source:Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
Author(s): Mads Bengtsen, Linda Sørensen, Linn Aabel, Marit Ledsaak, Vilborg Matre, Odd Stokke Gabrielsen
LIM-domain proteins, containing multiple cysteine-rich zinc finger-like motifs, have been shown to play diverse roles in several cellular processes. A common theme is that they mediate important protein-protein interactions that are key to their function. Androgen receptor-associated protein 55 (ARA55) belongs to this family of bridging proteins containing four C-terminal LIM domains. It has a dual role with functions both at focal adhesions and in the nucleus, apparently shuttling between the two compartments. In the present work, we have expanded our understanding of its nuclear functions by showing that it interacts with three nuclear regulators not previously linked to ARA55. We first identified ARA55 as a novel interaction partner of the nuclear kinase HIPK1 and found that ARA55, like HIPK1, also interacts with the transcription factor c-Myb. In search of a function for these associations, we observed that the coactivator p300 not only binds to c-Myb, but to ARA55 as well. When combined, c-Myb, p300, HIPK1 and ARA55 caused strong synergistic activation of a chromatinized reporter gene. In parallel, all partners, including p300, were efficiently recruited to chromatin at the c-Myb-bound promoter. Consistent with this cooperation, we found that c-Myb and ARA55 share a common set of target genes in an osteosarcoma cellular context. We propose that ARA55 and HIPK1 assist c-Myb in recruiting the coactivator and acetyltransferase p300 to chromatin.
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Regional anaesthesia for ophthalmic surgery
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Acute respiratory distress syndrome
<span class="paragraphSection"><div class="boxedTextSection">Key points<ul><li class="bullet">Acute respiratory distress syndrome (ARDS) is commonly encountered in the critical care population and is associated with a high mortality of between 27% and 45%.</li><li class="bullet">ARDS is diagnosed according to the Berlin definition and is characterized as mild, moderate, or severe depending on the <span style="font-style:italic;">P</span>a<span style="text-transform:lowercase;font-variant:small-caps;">O</span><sub>2</sub>/<span style="font-style:italic;">FI</span><span style="text-transform:lowercase;font-variant:small-caps;">O</span><sub>2</sub> ratio.</li><li class="bullet">Accepted management strategies include lung protective ventilation with tidal volumes limited to 6 ml kg<sup>−</sup><sup>1</sup>, positive end expiratory pressure increasing in line with oxygen requirement, and prone positioning in severe cases.</li><li class="bullet">Steroids, statins, inhaled nitric oxide, and high-frequency oscillation ventilation do not have a role in the routine management of adults with ARDS.</li><li class="bullet">Adverse functional and neuropsychological outcomes are increasingly recognized in long-term ARDS survivors.</li></ul></div></span>
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Primary Biliary Cholangitis: advances in management and treatment of the disease.
Primary Biliary Cholangitis, previously known as Primary Biliary Cirrhosis, is a rare disease, which mainly affects women in their fifth to seventh decades of life. It is a chronic autoimmune disease characterized by a progressive damage of interlobular bile ducts leading to ductopenia, chronic cholestasis and bile acids retention. Even if the disease usually presents a long asymptomatic phase and a slow progression, in many patients it may progress faster toward cirrhosis and its complications.
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Alzheimer's disease disrupts alpha and beta-band resting-state oscillatory network connectivity
Alzheimer's disease (AD) is a progressive degenerative disease, affecting memory and other cognitive functions. The neural characteristics of AD are structural changes such as widespread atrophy and deposits of amyloid plaques and tau protein neurofibrillary tangles, particularly in the hippocampus, entorhinal cortex and post-central parietal areas (Lizio et al. 2011).
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