β-Glucan, a dietary fiber in effective prevention of lifestyle diseases – An insightPublication date: Available online 11 May 2019Source: Bioactive Carbohydrates and Dietary FibreAuthor(s): Gunjan Maheshwari, Sumathi Sowrirajan, Baby JosephAbstractβ-Glucan (β-G), a dietary fiber and a biologically active natural polysaccharide, is helpful in the prevention and control of obesity, cardiovascular diseases, diabetics and cancer. Witnessing an increasing trend in mortality due to these diseases, especially...
Prophylaxis in High-Risk Patients With eGFR < 30 mL/min/1.73 m2: Get the Balance Right Objectives...Prophylaxis in High-Risk Patients With eGFR < 30 mL/min/1.73 m2: Get the Balance RightObjectives Clinical guidelines recommend prophylactic intravenous fluids for patients with estimated glomerular filtration rate (eGFR) less than 30 mL/min/1.73 m2 to prevent adverse postcontrast outcomes. These patients represent a small minority of the population receiving intravascular iodinated contrast material,...
Prophylaxis in High-Risk Patients With eGFR < 30 mL/min/1.73 m2: Get the Balance Right Objectives...
Prophylaxis in High-Risk Patients With eGFR < 30 mL/min/1.73 m2: Get the Balance RightObjectives Clinical guidelines recommend prophylactic intravenous fluids for patients with estimated glomerular filtration rate (eGFR) less than 30 mL/min/1.73 m2 to prevent adverse postcontrast outcomes. These patients represent a small minority of the population receiving intravascular iodinated contrast material, and data are not readily available. The current study aim is to gain insight into positive and...
Preventive Effect of Changing Contrast Media in Patients With A Prior Mild Immediate Hypersensitivity Reaction to Gadolinium-Based Contrast AgentObjectives Currently, the prevention of recurrent immediate hypersensitivity reactions (HSRs) to contrast media (CM) requests premedication and changing the culprit contrast agent. However, strategies for the prevention of immediate HSRs to gadolinium-based magnetic resonance contrast agents (GBCAs) have not yet been established. This study aimed to evaluate...
Evaluation of Gadopiclenol and P846, 2 High-Relaxivity Macrocyclic Magnetic Resonance Contrast Agents Without Protein Binding, in a Rodent Model of Hepatic Metastases: Potential Solutions for Improved Enhancement at Ultrahigh Field StrengthPurpose The aim of this study was to evaluate in vitro and in vivo the enhancement properties of experimental gadolinium (Gd)-based contrast agents (GBCAs) with different molecular weights and hydration numbers (P846 and gadopiclenol) compared with clinically approved...
Increased Retention of Gadolinium in the Inflamed Brain After Repeated Administration of Gadopentetate Dimeglumine: A Proof-of-Concept Study in Mice Combining ICP-MS and Micro– and Nano–SR-XRFObjectives The aim of this study was to determine in vivo if brain inflammation leads to increased gadolinium (Gd) retention in brain tissue after repeated applications of Gd-based contrast agents (GBCAs). Materials and Methods Experimental autoimmune encephalomyelitis (EAE) was induced in female SJL/J mice...
Super-Resolution Contrast-Enhanced Ultrasound Methodology for the Identification of In Vivo Vascular Dynamics in 2DObjectives The aim of this study was to provide an ultrasound-based super-resolution methodology that can be implemented using clinical 2-dimensional ultrasound equipment and standard contrast-enhanced ultrasound modes. In addition, the aim is to achieve this for true-to-life patient imaging conditions, including realistic examination times of a few minutes and adequate image penetration...
Computer-Aided Diagnosis of Pulmonary Fibrosis Using Deep Learning and CT ImagesObjectives The objective of this study is to assess the performance of a computer-aided diagnosis (CAD) system (INTACT system) for the automatic classification of high-resolution computed tomography images into 4 radiological diagnostic categories and to compare this with the performance of radiologists on the same task. Materials and Methods For the comparison, a total of 105 cases of pulmonary fibrosis were studied...
Gadolinium-Based MRI Contrast Agents Induce Mitochondrial Toxicity and Cell Death in Human Neurons, and Toxicity Increases With Reduced Kinetic Stability of the AgentObjectives This preclinical study was devised to investigate potential cellular toxicity in human neurons induced by gadolinium-based contrast agents (GBCAs) used for contrast-enhanced magnetic resonance imaging (MRI). Neurons modeling a subset of those in the basal ganglia were tested, because the basal ganglia region is 1 of 2 brain...
Imaging Features of Hepatocellular Carcinoma: Quantitative and Qualitative Comparison Between MRI-Enhanced With Gd-EOB-DTPA and Gd-DTPAObjectives The aim of this study was to compare the major imaging features of hepatocellular carcinoma (HCC) on magnetic resonance imaging (MRI) scans with Gd-EOB-DTPA (EOB) and extracellular agent (ECA; Gd-DTPA) contrast media. Materials and Methods Among 184 surgically proven HCCs in 169 patients who underwent a liver MRI with either EOB (n = 120) or ECA (n = 49),...
AcidoCEST-UTE MRI for the Assessment of Extracellular pH of Joint Tissues at 3 TObjectives The goal of this study was to demonstrate feasibility of measuring extracellular pH in cartilage and meniscus using acidoCEST technique with a 3-dimensional ultrashort echo time readout (acidoCEST-UTE) magnetic resonance imaging (MRI). Materials and Methods Magnetization transfer ratio asymmetry, radiofrequency (RF) power mismatch, and relative saturation transfer were evaluated in liquid phantoms for iopromide,...
Comparison of the Relaxivities of Macrocyclic Gadolinium-Based Contrast Agents in Human Plasma at 1.5, 3, and 7 T, and Blood at 3 TPurpose The relaxivities of 3 macrocyclic gadolinium-based contrast agents (GBCAs) were determined in human plasma and blood under standardized and clinically relevant laboratory conditions. Methods The T1 relaxivity, r1, was determined in human plasma at 1.5, 3, and 7 T, and in human blood at 3 T at 37°C in phantoms containing 4 different concentrations of the macrocyclic...
Comparison of the Relaxivities of Macrocyclic Gadolinium-Based Contrast Agents in Human Plasma at 1.5, 3, and 7 T, and Blood at 3 TPurpose The relaxivities of 3 macrocyclic gadolinium-based contrast agents (GBCAs) were determined in human plasma and blood under standardized and clinically relevant laboratory conditions. Methods The T1 relaxivity, r1, was determined in human plasma at 1.5, 3, and 7 T, and in human blood at 3 T at 37°C in phantoms containing 4 different concentrations of the macrocyclic...
The Revised Hearing Handicap Inventory and Screening Tool Based on Psychometric Reevaluation of the Hearing Handicap Inventories for the Elderly and AdultsObjectives: The present study evaluates the items of the Hearing Handicap Inventory for the Elderly and Hearing Handicap Inventory for Adults (HHIE/A) using Mokken scale analysis (MSA), a type of nonparametric item response theory, and develops updated tools with optimal psychometric properties. Design: In a longitudinal study of age-related hearing...
Assessment of some biomarkers of inflammation in breast cancer patients in Benin City, NigeriaEboreime Ofunre, Atoe Kenneth, Idemudia Joseph OsagieNigerian Journal of Surgical Sciences 2017 27(2):33-36Introduction: Inflammation has been shown to play a major role in the pathogenesis of most malignancies including breast cancer. The inflammatory basis of breast cancer has not been evaluated in our environment. Objective: The purpose of this study is to determine the level of some biomarkers of systemic...
Hysterosalpingographic findings in women with infertility in Awka, Anambra State, South-East NigeriaSamuel Iloraah Udobi, Michael Echeta AronuNigerian Journal of Surgical Sciences 2017 27(2):47-50Background: Infertility is a major concern among couples in our environment. Hysterosalpingography (HSG) is a radiological procedure used to investigate women with infertility. It can be used to assess the cervical canal, the uterine cavity, and the fallopian tubes in these women. So far, the pattern of...
Prostatic adenocarcinoma and prostatic intraepithelial neoplasia: A tale of the autopsy model in a Nigerian tertiary hospitalDele Eradebamwen Imasogie, Akhator Terence AzekeNigerian Journal of Surgical Sciences 2017 27(2):41-46Introduction: The frequency of clinical prostatic adenocarcinoma and high-grade prostatic intraepithelial neoplasia (HGPIN) in a certain population could be similar to the prevalent model of latent adenocarcinoma as well as to the frequency and extent of HGPIN. The aim of this...
Cervical cancer: Risk factors and uptake of screening among expectant mothers in AbakalikiGlory I Urom, Emeka O Omabe, Nkechi J Okoli, Ndubuisi S Eze, Ben N Azuogu, Odidika U J UmeoraNigerian Journal of Surgical Sciences 2017 27(2):37-40Context: cancer remains the most common reason for death from gynaecological malignancy in Nigeria while screening remains opportunistic. Pregnancy provides a veritable ample opportunity for screening for this malignancy. Aim: to evaluate the risk factors for cervical...
Assessment of some biomarkers of inflammation in breast cancer patients in Benin City, NigeriaEboreime Ofunre, Atoe Kenneth, Idemudia Joseph OsagieNigerian Journal of Surgical Sciences 2017 27(2):33-36Introduction: Inflammation has been shown to play a major role in the pathogenesis of most malignancies including breast cancer. The inflammatory basis of breast cancer has not been evaluated in our environment. Objective: The purpose of this study is to determine the level of some biomarkers of systemic...
REVIEW ARTICLEJ Carcinog2019, 18:2Immunotherapy in breast cancerSoley Bayraktar1, Sameer Batoo2, Scott Okuno2, Stefan Glück31 Department of Medicine, Division of Medical Oncology and Hematology, Mayo Clinic Health System, Eau Claire, WI, USA; Department of Medicine, Division of Medical Oncology and Hematology, Biruni University School of Medicine, Istanbul, Turkey2 Department of Medicine, Division of Medical Oncology and Hematology, Mayo Clinic Health System, Eau Claire, WI, USA3 Vice President...
ORIGINAL ARTICLEJ Carcinog2019, 18:1Assessment and clinicopathological correlation of matrix metalloproteinase 9 expression in nasopharyngeal carcinomaAshok Kumar Das1, Nizara Baishya1, Anupam Sarma2, Amal Chandra Kataki3, Avdesh Kumar Rai4, Chandi Ram Kalita51 Department of Head and Neck Oncology, Dr. B. Borooah Cancer Institute, Guwahati, Assam, India2 Department of Pathology, Dr. B. Borooah Cancer Institute, Guwahati, Assam, India3 Department of Gynae Oncology, Dr. B. Borooah Cancer Institute,...
Contemporary management of frontal sinus fractures Purpose of review Frontal sinus fracture management...Contemporary management of frontal sinus fracturesPurpose of review Frontal sinus fracture management is evolving. This article will highlight recent literature and provide an evidence-based algorithm in the contemporary management of frontal sinus fractures. Recent findings The role of transnasal endoscopic treatment of frontal sinus fractures has expanded to include fracture reduction and posterior...
Contemporary management of frontal sinus fracturesPurpose of review Frontal sinus fracture management is evolving. This article will highlight recent literature and provide an evidence-based algorithm in the contemporary management of frontal sinus fractures. Recent findings The role of transnasal endoscopic treatment of frontal sinus fractures has expanded to include fracture reduction and posterior table reconstruction. Evidence continues to support the safety of nonoperative management in select...
empty nose syndrome: disease mechanisms, diagnostic tools, and treatment strategiesPurpose of review To discuss the proposed pathophysiology of empty nose syndrome (ENS), summarize and evaluate the role of validated diagnostic tools in the diagnosis of ENS, and review the medical and surgical treatment strategies for patients with ENS. Recent findings Historically, ENS has been associated with a reduction in nasal turbinate size; new data suggest that impaired trigeminal nerve function may also play...
Update on empty nose syndrome: disease mechanisms, diagnostic tools, and treatment strategiesPurpose of review To discuss the proposed pathophysiology of empty nose syndrome (ENS), summarize and evaluate the role of validated diagnostic tools in the diagnosis of ENS, and review the medical and surgical treatment strategies for patients with ENS. Recent findings Historically, ENS has been associated with a reduction in nasal turbinate size; new data suggest that impaired trigeminal nerve function...
Harnessing heat for diagnosis and therapyNagraj Gururaj HuilgolJournal of Radiation and Cancer Research 2019 10(1):77-78Hyperthermia is an important adjunct to radiation therapy and chemotherapy. Heat includes in cellular organelle, cell membrane and vasculature. The changes can't be measured and imaged using magnetic resonance imaging. Currently, MRI thermometry is available while cellular and structural changes following heat for the purpose of diagnostics and prognostication needs further exploration....
urban adult addiction patternShradha G Jaiswal, Digpal Dharkar, Rajeev ShrivastavJournal of Radiation and Cancer Research 2019 10(1):72-76Introduction: Oral cancer is a multifactorial disease, which is largely preventable. Awareness about cancer and its risk factors and symptoms can lead to prevention and early clinical diagnosis. Proper monitoring of the high-risk population along with periodic follow-up and deaddiction protocol can help reduce the incidence of oral cancer and lead to an early clinical...
Protective action of picroliv isolated from Picrorhiza kurroa against radiation clastogenecity on...
Protective action of picroliv isolated from Picrorhiza kurroa against radiation clastogenecity on mice and cyclophosphamide-induced cytotoxicity in Allium cepa RootPapiya Bigoniya, Ankita Warathe, Chandra Shekar SinghJournal of Radiation and Cancer Research 2019 10(1):58-65Objective: Wide-scale cell death, following chemo and radiation therapy, is a major concern in clinical therapy of cancer. The need to identify agents with a potential for chemo and radioprotective potential has assumed great...
Water-soluble version of SCR7-pyrazine inhibits DNA repair and abrogates tumor cell proliferationMonica Pandey, Vidya Gopalakrishnan, Hassan A Swarup, Sujeet Kumar, Radha Gudapureddy, Anjana Elizabeth Jose, Supriya V Vartak, Robin Sebastian, Mrinal Srivastava, Bibha Choudhary, Mantelingu Kempegowda, Subhas S Karki, Sathees C RaghavanJournal of Radiation and Cancer Research 2019 10(1):27-43Aim: Mammalian DNA Ligases play pivotal role in processes such as DNA replication, recombination, and repair,...
radiation-induced gene expression arrays following radioprotection with amifostineThomas M Seed, Vijay K Singh, Briana K HanlonJournal of Radiation and Cancer Research 2019 10(1):44-57Aims and Objectives: The study objective was to investigate differential gene expression in lymphohematopoietic tissues (spleens) of mice injected with amifostine and exposed to sublethal doses of 60Co γ-radiation. Materials and Methods: Differential cDNA gene expression arrays were used to examine early- (1 day) and...
High-dose interstitial brachytherapy for accelerated partial-breast irradiation in clinical practice: Preliminary results from a tertiary cancer center in IndiaVijay Palwe, Prakash Pandit, Rajnish Nagarkar, Nishtha PalejaJournal of Radiation and Cancer Research 2019 10(1):24-26Introduction: Over the past several years, there has been growing interest in the use of accelerated partial-breast irradiation (APBI) as an alternative to whole-breast radiation in properly selected patients. The use of multicatheter...
hyperthermia along with radiotherapy on the outcomes of treatment in locally advanced carcinoma cervixVibha Saluja, Rohit Dusane, Nagraj HuilgolJournal of Radiation and Cancer Research 2019 10(1):18-23Aims: The present study was aimed to assess the impact of Hyperthermia along with Radiotherapy on the outcomes of treatment in locally advanced carcinoma cervix. Materials and Methods: Present study is a retrospective analysis of cancer cervix patients treated with radiotherapy and hyperthermia+/- chemotherapy...
Thermal and nonthermal effects of radiofrequency on living state and applications as an adjuvant with radiation therapyAndras SzaszJournal of Radiation and Cancer Research 2019 10(1):1-17One of the most frequently applied bioelectromagnetic effects is the deep heating of living species with electromotive force energy. Despite its long history, hyperthermia is a rarely applied oncotherapy because of controversial results and complicated control. The challenge in clinical studies of oncological hyperthermia...
exercise in patients who undergo allogeneic hematopoietic stem cell transplantationShinichiro Morishita, Atsuhiro Tsubaki, Kazuki Hotta, Jack B Fu, Shigeo FujiThe Journal of the International Society of Physical and Rehabilitation Medicine 2019 2(1):54-61Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is increasingly used in the treatment of hematologic cancers such as leukemias, lymphomas, and myeloma and for other hematologic disorders such as primary immunodeficiency, aplastic anemia,...
independent walking in elderly inpatients with collagen diseasesShinya Yamauchi, Shinichiro Morishita, Yuki Uchiyama, Norihiko Kodama, Kazuhisa DomenThe Journal of the International Society of Physical and Rehabilitation Medicine 2019 2(1):30-34Purpose: In elderly patients with collagen disease, walking ability tends to decrease due to treatment with corticosteroids and long-term hospitalization. The purpose of this study was to investigate the factors related to independent walking in elderly patients...
poststroke shoulder painTarek Saad Shafshak, Mowaffak Moustafa Abdelhamid, Mohamed Ihab Samy Reda, Marwa Abdullah AmerThe Journal of the International Society of Physical and Rehabilitation Medicine 2019 2(1):35-41Background: Poststroke shoulder pain (PSSP) is a complex phenomenon. Defining the exact etiology would facilitate proper management. Aim: The aim of the study is to identify the different causes of PSSP. Settings and Design: Observational cross-sectional study at institution, university...
Postbreast cancer surgery outpatient rehabilitation program: Analysis of clinical profile, impact, and direct medical costsMarina Boralli de Sousa, Camila da Silva Bueno, Rossana Veronica Mendoza Lopez, Elisângela Pinto Marinho de Almeida, Rebeca Boltes Cecatto, Christina May Moran de BritoThe Journal of the International Society of Physical and Rehabilitation Medicine 2019 2(1):22-29Context: Approximately 600,000 new cases of cancer are estimated to occur in Brazil over the 2-year period of 2018–2019,...
The international society of physical and rehabilitation medicine: The past, present, and way forward-IIIJorge Lains, Francesca Gimigliano, Jianan Li, Leonard Li, Sam Wu, Louise Gorringe, Linda Bosschers, Walter FronteraThe Journal of the International Society of Physical and Rehabilitation Medicine 2019 2(1):1-11This article is meant as an update on the previous articles published about the International Society of Physical and Rehabilitation Medicine (ISPRM). It reflects the current organizational...
acupressure therapy on quality of recovery after surgeryBACKGROUND Acupressure therapy is associated with favourable efficacies on postoperative nausea, pain and sleep disturbance, although the quality of the evidence is generally low. No randomised clinical trial has yet assessed the effect of acupressure on postoperative quality of recovery (QoR). OBJECTIVE The objective was to study acupressure efficacy on patient-reported postoperative recovery. DESIGN We conducted a single centre, three-group,...
Deep neuromuscular blockade improves surgical conditions during gastric bypass surgery for morbid obesity: A randomised controlled trialBACKGROUND There is a controversy in the literature whether deep compared with moderate neuromuscular block (NMB) improves surgical conditions for laparoscopic surgery. OBJECTIVES The primary outcome measure was to examine whether switching from moderate to deep NMB improves surgical conditions for laparoscopic surgery in the obese; secondary outcome measures were...
Effect of pre-operative oral carbohydrate loading on recovery after day-case cholecystectomy: A randomised controlled trialBACKGROUND Pre-operative carbohydrate loading has been shown to reduce pre-operative discomfort and postoperative nausea and vomiting in general surgical patients. Few studies have considered day-case surgery. OBJECTIVE The aim of this prospective randomised study was to determine whether pre-operative carbohydrate loading enhanced recovery after day-case cholecystectomy. DESIGN...
Can quantitative sensory tests predict failed back surgery?: A prospective cohort studyBACKGROUND Failed back surgery syndrome (FBSS) is a pain condition refractory to therapy, and is characterised by persistent low back pain after spinal surgery. FBSS is associated with severe disability, low quality of life and high unemployment. We are currently unable to identify patients who are at risk of developing FBSS. Patients with chronic low back pain may display signs of central hypersensitivity as assessed...
Tidal volume challenge to predict fluid responsiveness in the operating room: A prospective trial on neurosurgical patients undergoing protective ventilationBACKGROUND Pulse pressure variation (PPV) and stroke volume variation (SVV) do not predict fluid responsiveness when using a protective ventilation strategy: the use of functional haemodynamic tests can be useful to overcome this limitation. OBJECTIVES We tested the use of a tidal volume challenge (VTC), during 6 ml kg−1 [predicted body weight...
Colour Doppler ultrasound after major cardiac surgery improves diagnostic accuracy of the pulmonary infection score in acute respiratory failure: A prospective observational studyBACKGROUND Postoperative pneumonia is a frequent complication after cardiac surgery, and its diagnosis is difficult. Little is known about the diagnostic accuracy of lung ultrasound (LUS) in the detection of pneumonia in cardiac surgical patients. The substitution of chest radiography by colour Doppler LUS (LUS-sCPIS) in...
Propofol intravenous anaesthesia with desflurane compared with desflurane alone on postoperative liver function after living-donor liver transplantation: A randomised controlled trialBACKGROUND Propofol is an anaesthetic that resembles α-tocopherol and it has been suggested that it protects against ischaemia-reperfusion injury in liver transplantation. Living-donor liver transplantation (LDLT) presents an opportunity to test this hypothesis in both donors and recipients. OBJECTIVES We compared clinical...
Reintubation in the ICU following cardiac surgery: is it more difficult than first-time intubation in the operating room?: A prospective, observational studyBACKGROUND After cardiac surgery, a patient's trachea is usually extubated; however, 2 to 13% of cardiac surgery patients require reintubation in the ICU. OBJECTIVE The objective of this study was to compare the initial intubation in the cardiac operating room with reintubation (if required) in the ICU following cardiac surgery. DESIGN A prospective,...
Effect of sevoflurane-based or propofol-based anaesthesia on the incidence of postoperative acute kidney injury: A retrospective propensity score-matched analysisBACKGROUND Propofol may help to protect against ischaemic acute kidney injury (AKI); however, research on this topic is sparse. OBJECTIVE The current study aimed to investigate whether there were differences in the incidence of postoperative AKI after lung resection surgery between patients who received propofol-based total intravenous anaesthesia...
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