Cancer Medicine

Survival after radiotherapy versus radical cystectomy for primary muscle‐invasive bladder cancer: A Swedish nationwide population‐based cohort study

In this study, we investigated the risk of death after radiotherapy as compared to radical cystectomy for muscle‐invasive bladder cancer, and found different results for different methods used. For a selected group of patients, we found similar survival after the two treatments; this patient group could serve as a basis for future comparison studies.AbstractBackgroundStudies of survival comparing radical cystectomy (RC) and radiotherapy for muscle‐invasive bladder cancer have provided inconsistent...

Cancer Medicine

Mon Apr 01, 2019 18:02

Long non‐coding RNA PCAT6 targets miR‐204 to modulate the chemoresistance of colorectal cancer cells to 5‐fluorouracil‐based treatment through HMGA2 signaling

In the present study, we demonstrated that PCAT6 could modulate CRC chemoresistance to 5‐FU‐based chemotherapy through miR‐204/HMGA2/PI3K; PCAT6 represents a promising target for dealing with CRC chemoresistance.AbstractColorectal cancer (CRC) is still the third most common cancer in the world with a limited prognosis due to the chemoresistance of CRC cells to 5‐fluorouracil (5‐FU)‐based chemotherapy. In our previous study, we revealed that miR‐204 overexpression could sensitize CRC cell...

Cancer Medicine

Mon Apr 01, 2019 18:01

Deciphering the scalene association among type‐2 diabetes mellitus, prostate cancer, and chronic myeloid leukemia via enrichment analysis of disease‐gene network

There is a "scalene" relationship among T2DM, CML, and PCa at gene, pathway, biological process, and module levels: CML and PCa were the most closely related, the second were T2DM and PCa, and T2DM and PCa were the least related pair in our study. Our study provides a new avenue for further studies on T2DM and cancers, which may promote the discovery and development of novel therapeutic and can be used to treat multiple diseases.AbstractThe potential biological relationship between type‐2...

Cancer Medicine

Mon Apr 01, 2019 18:00

Clinical and histopathological characteristics and survival analysis of 4594 Japanese patients with melanoma

AbstractBackgroundThe incidence of melanoma among those of an Asian ethnicity is lower than in Caucasians; few large‐scale Asian studies that include follow‐up data have been reported.ObjectivesTo investigate the clinical characteristics of Japanese patients with melanoma and to evaluate the prognostic factors.MethodsDetailed patient information was collected from the database of Japanese Melanoma Study Group of the Japanese Skin Cancer Society. The American Joint Committee on Cancer seventh...

Cancer Medicine

Mon Apr 01, 2019 13:03

Identification of competitive endogenous RNAs network in breast cancer

Identification of differentially expressed lncRNAs (DELs), mRNAs (DEMs), and miRNAs (DEMis) in breast cancer. Construction of competing endogenous RNA (ceRNA) regulatory network and screening new treatment and prognosis targets and biomarkers for breast cancer.AbstractBackgroundMiRNAs can regulate gene expression directly or indirectly, and long noncoding RNAs as competing endogenous RNA (ceRNAs) can bind to miRNAs competitively and affect mRNA expression. The ceRNA network is still unclear...

Cancer Medicine

Mon Apr 01, 2019 12:31

PHD finger protein 5A promoted lung adenocarcinoma progression via alternative splicing

We demonstrated that PHF5A acted as a key regulator in the AS of many essential genes to promote the development and progression of LUAD. PHF5A might serve as a potential drug target with a promising anticancer therapeutic effect in LUAD patients.AbstractAlternative splicing (AS) and the regulation of AS by splicing factors play critical roles in cancer. Plant homeodomain (PHD)–finger domain protein PHF5A, a critical splicing factor involved in AS, has been demonstrated to play an oncogenic...

Cancer Medicine

Mon Apr 01, 2019 12:29

Survey of dentin sialophosphoprotein and its cognate matrix metalloproteinase‐20 in human cancers

Our data provide a major reference and baseline document for studies on the role, mechanism, and significance of MMP20‐DSPP expression in major human epithelial neoplasms. In this respect, it is both significant and novel. Furthermore, future findings may offer new opportunities for intervention in epithelial cancers. For example, in cancers in which both MMP20 and its DSPP partner are upregulated, any synthetic MMP protease inhibitor that may be proposed to be used to treat the disorder...

Cancer Medicine

Mon Apr 01, 2019 12:29

Using adaptive magnetic resonance image‐guided radiation therapy for treatment of inoperable pancreatic cancer

Adaptive magnetic resonance imaging (MRI)‐guided radiation therapy (RT) is a novel method to deliver dose‐escalated RT to inoperable pancreatic tumors. Dose‐escalated adaptive MRI‐guided RT improved survival without compromising safety.AbstractBackgroundAdaptive magnetic resonance imaging‐guided radiation therapy (MRgRT) can escalate dose to tumors while minimizing dose to normal tissue. We evaluated outcomes of inoperable pancreatic cancer patients treated using MRgRT with and without dose...

Cancer Medicine

Mon Apr 01, 2019 12:29