Caffeine Augments the Prothrombotic but Not the Fibrinolytic Response to Exercise

Caffeine, a popular ergogenic supplement, induces neural and vascular changes that may influence coagulation and/or fibrinolysis at rest and during exercise. Purpose The purpose of this study was to assess the effect of a single dose of caffeine on measures of coagulation and fibrinolysis before and after a single bout of high-intensity exercise. Methods Forty-eight men (age, 23 ± 3 yr; body mass index, 24 ± 3 kg·m−2) completed two trials, with 6 mg·kg−1 of caffeine (CAFF) or placebo (PLAC), in random order, followed by a maximal cycle ergometer test. Plasma concentrations of fibrinogen, factor VIII antigen, active tissue plasminogen activator (tPA:c), tissue plasminogen activator antigen (tPA:g), and active plasminogen activator inhibitor-1 (PAI-1:c) were assessed at baseline and immediately after exercise. Results Exercise led to significant changes in tPA:c (Δ 8.5 ± 4.36 IU·mL−1 for CAFF, 6.6 ± 3.7 for PLAC), tPA:g (Δ 2.4 ± 3.2 ng·mL−1 for CAFF, 1.9 ± 3.1 for PLAC), fibrinogen (Δ 30.6 ± 61.4 mg·dL−1 for CAFF, 28.1 ± 66.4 for PLAC), and PAI-1:c (Δ −3.4 ± 7.9 IU·mL−1 for CAFF, −4.0 ± 12.0 for PLAC) (all P

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