Objectives: Parents of children with a chronic illness are at risk for impaired psychosocial functioning. Gastroesophageal reflux disease (GERD) is such a disease, and no studies have investigated effects of antireflux surgery on parental psychological distress. The aims of this study were to assess psychological distress and state and trait anxiety in mothers of children with GERD, and to explore possible changes after antireflux surgery. Methods: Mothers of children referred for antireflux surgery were included in this prospective study. Standardized questionnaires were used to evaluate psychological distress and state and trait anxiety before and twelve months after antireflux surgery. Results: Of 87 eligible mothers of children with GERD, 62 (71%) agreed to participate. All children had objectively verified GERD by 24-hour pH-monitoring and/or upper gastrointestinal contrast study and unsatisfactory symptom relief of pharmacological treatment. 31 (50%) mothers returned questionnaires postoperatively. Preoperatively, mothers of children undergoing antireflux surgery reported high levels of psychological distress and state anxiety, and 54% had scores indicating clinically significant psychological distress. None of the preoperative child characteristics were found to significantly influence maternal psychological distress or state anxiety. Twelve months postoperatively, both psychological distress and state anxiety were reduced. Conclusion: Mothers of children undergoing antireflux surgery reported reduced levels of psychological distress and state anxiety twelve months after the operation. Address correspondence and reprint requests to Morten Kvello, Department of Gastrointestinal and Pediatric surgery, Oslo University Hospital, Rikshospitalet, Postboks 4950 Nydalen, 0424 Oslo, NORWAY (. e-mail: m.kvello@gmail.com) Received 6 October, 2018 Accepted 5 January, 2019 Supplemental digital content is available for this article. Direct URL citations appear in the printed text, and links to the digital files are provided in the HTML text of this article on the journal's Web site (www.jpgn.org). Trial identification: www.clinicaltrial.gov, NCT01551134 Conflict of Interest and Source of Funding: The authors declare no conflicts of interest relevant to this article. M Kvello has received financial support from the University of Oslo Financial Disclosure: The authors declare no financial relationships relevant to this article. © 2019 by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology,
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