Chromatin accessibility and the regulatory epigenome

Chromatin accessibility and the regulatory epigenome

Chromatin accessibility and the regulatory epigenome, Published online: 23 January 2019; doi:10.1038/s41576-018-0089-8

Chromatin accessibility comprises the positions, compaction and dynamics of nucleosomes, as well as the occupancy of DNA by other proteins such as transcription factors. In this Review, the authors discuss diverse methods for characterizing chromatin accessibility, how accessibility is determined and remodelled in cells and the regulatory roles of accessibility in gene expression and development.

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