Prevalence of Eosinophilic Esophagitis in Adolescents with Esophageal Atresia

Background and objective: Eosinophilic esophagitis (EoE) is an increasingly recognized childhood disease. Esophageal atresia (EA) is the most frequent congenital malformation of the esophagus. Recently, cases of EoE occurring in patients with EA have been reported, although the exact prevalence of EoE in EA remains unknown. The aim is to investigate the prevalence of EoE among EA in adolescents and to describe these patients' characteristics. Methods: Systematic upper gastrointestinal endoscopies with multistage esophageal biopsies were prospectively performed in 63 adolescents with EA. A standardized form was used to collect clinical and endoscopic data. Diagnosis of EoE was made as ≥ 15 intraepithelial eosinophils/high power field (HPF), whatever the response on proton pump inhibitors (PPI) therapy. Results: Six patients (9.5%) presented an EoE (17 to 100 eosinophils/HPF). An atopic condition was reported more frequently in the Eo ≥ 15 group than in patients with no EoE (66% vs 16%; P = 0.014). Except for chest pain, symptoms and endoscopic features were similar in patients with EoE and patients with no EoE. Conclusion: In our series of 63 patients born with EA, mainly distal tracheoeosophageal fistula, the prevalence of EoE is increased and therefore should be considered in adolescents with EA. Address correspondence and reprint requests to Emilie Lardenois, MD, CHU de Nancy, service d'anatomopathologie, Hôpital central, 29 avenue du maréchal de Lattre de Tassigny, 54000 Nancy, France (E-mail: E.LARDENOIS@chru-nancy.fr). Received 12 July, 2018 Accepted 1 December, 2018 Funding Source: No funding was secured for this study. Financial Disclosure: The authors have no financial relationships relevant to this article to disclose. The authors have no conflicts of interest relevant to this article to disclose. © 2019 by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology,

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