Τρίτη 15 Ιανουαρίου 2019

Constitutive Dicer1 phosphorylation accelerates metabolism and aging in vivo [Genetics]

DICER1 gene alterations and decreased expression are associated with developmental disorders and diseases in humans. Oscillation of Dicer1 phosphorylation and dephosphorylation regulates its function during the oocyte-to-embryo transition in Caenorhabditis elegans. Dicer1 is also phosphorylated upon FGF stimulation at conserved serines in mouse embryonic fibroblasts and HEK293 cells. However, whether...

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