Two-Day Residence at 2500 m to 4300 m Does Not Affect Subsequent Exercise Performance at 4300 m

PURPOSE To determine the efficacy residing for two days at various altitudes while sedentary (S) or active (A; ~90 min hiking 2•day-1) on exercise performance at 4300m. METHODS SL resident men (n=45) and women (n=21) (mean±SD; 23±5 yr; 173±9 cm; 73±12 kg; VO2peak= 49±7 ml•kg-1•min-1) were randomly assigned to a residence group and, S or A within each group: 2500m (n=11S, 8A); 3000m (n=6S, 12A); 3500m (n=6S, 8A); or 4300m (n=7S, 8A). Exercise assessments occurred at SL and 4300 m after 2 days residence and consisted of 20 min of steady-state (SS) treadmill walking (45±3% SL VO2peak) and a 5-mile, self-paced running time-trial (TT). Arterial oxygen saturation (SpO2) and heart rate (HR) were recorded throughout exercise. Resting SpO2 was recorded at SL, at 4 and 46 hrs of residence, and at 4300 m prior to exercise assessment. To determine if 2-day altitude residence improved 4300 m TT performance, results were compared to estimated performances using a validated prediction model. RESULTS For all groups, resting SpO2 was reduced (P

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