Towards quantitative and multiplexed in vivo functional cancer genomics
Towards quantitative and multiplexed in vivo functional cancer genomics, Published online: 28 September 2018; doi:10.1038/s41576-018-0053-7
CRISPR–Cas genome editing and next-generation sequencing are driving advances in cancer modelling and functional cancer genomics. Their application to autochthonous mouse models of human cancer to generate and analyse multiplexed and/or combinatorial alterations in vivo is reviewed here.
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