The m6A‑methylase complex and mRNA export

Publication date: Available online 2 October 2018

Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms

Author(s): Simon Lesbirel, Stuart A. Wilson

Abstract

During synthesis, mRNA undergoes a number of modifications such as capping, splicing and polyadenylation. These processes are coupled with the orderly deposition of the TREX complex on the mRNA and subsequent recruitment of the NXF1-P15 heterodimer which stimulates the nuclear export of mature mRNAs. mRNAs also undergo a number of internal modifications, the most common of which is the N⁶‑methyladenosine (m⁶A) modification. In this review we discuss the recent evidence of coupling between the m⁶A modification, RNA processing and export.

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