Τρίτη 23 Οκτωβρίου 2018

Human mitochondrial degradosome prevents harmful mitochondrial R loops and mitochondrial genome instability [Genetics]

R loops are nucleic acid structures comprising an DNA–RNA hybrid and a displaced single-stranded DNA. These structures may occur transiently during transcription, playing essential biological functions. However, persistent R loops may become pathological as they are important drivers of genome instability and have been associated with human diseases. The mitochondrial...

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