Fibromyalgia: increased reactivity of the muscle membrane and a role of central regulation

Fibromyalgia (FM) is a chronic pain condition of unknown etiology and unclear pathophysiology. FM is characterized by widespread, especially tendomuscular, pain and generalized hypersensitivity to pain (Mease, 2005; Wolfe and Rasker, 2013; Yunus, 2008). There is evidence of hyperactivation/deregulation at various levels of the central nervous system (Banic et al., 2004; Burgmer et al., 2012; Choi et al., 2016; Desmeules et al., 2003; Gracely et al., 2002; Truini et al., 2015; Yunus, 2008). In addition, there is growing evidence of muscular function disturbance (Ge et al., 2009; Hubbard and Berkoff, 1993; Klaver-Krol, 2017; Vitali et al., 1989).

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