Exercise-induced Changes in Soluble ST2 Concentrations in Marathon Runners

Purpose Previous studies have suggested that extreme endurance exercise may induce cardiac micro-damage that could lead to subsequent myocardial fibrosis. Soluble suppression of tumorigenicity (sST2) is a cardiac biomarker for assessment of myocardial fibrosis, inflammation and strain. We evaluated baseline and exercise-induced sST2 concentrations in a heterogeneous cohort of marathon runners to identify predictors for sST2 concentrations. Methods Ninety-two runners supplied demographic data, health status, physical activity levels and marathon experience. Before (baseline) and immediately after (finish) the marathon blood was drawn for analysis of sST2 and cTnI. Results Eighty-two participants (45±8 yrs, 79% male) finished the race in 227±28 min at 92 [88-94]% of their predicted maximum heart rate (exercise intensity). sST2 concentrations increased in all runners, from 34 [25-46] ng/ml to 70 [53-87] ng/ml (p<.001 and ctni increased from ng to sst2 concentrations were higher in the fastest marathon runners. sex personal best time associated with baseline weight loss exercise intensity during finish height weekly training hours exercise-induced increase we observed no association between concentrations. conclusion an was all runners exceeding cut-off values both at faster had our data suggest complex variables determine author for correspondence: vincent aengevaeren department of physiology radboud university medical center p.o. box hb nijmegen netherlands tel fax e-mail: vincent.aengevaeren v.l.a is financially supported by a grant institute health sciences. j.l.j partially hutter family professorship. t.m.h.e horizon european commission sklodowska-curie fellowship would like thank critical diagnostics analyses samples. conflict interest: j.v.s. chief scientific officer president diagnostics. results present study do not constitute endorsement acsm. declare that are presented clearly honestly without fabrication falsification or inappropriate manipulation. accepted publication: october american college sports medicine>

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