Maternal Physical Activity and Sex Impact Markers of Hepatic Mitochondrial Health

Introduction Maternal exercise and physical activity during the gestational period can be protective against maternal high-fat diet–induced hepatic steatosis in older offspring. However, it is unknown whether these protective effects are seen in younger offspring. In this study, we investigated whether maternal physical activity would attenuate maternal western diet (WD)–induced steatosis in young adult rats. Methods Female Wistar rats (7–8 wk of age) were randomized into WD (42% fat, 27% sucrose) or normal chow diet (ND), and further randomized into physical activity (RUN) or sedentary (SED) conditions for a total of four groups. Dams returned to ND/SED conditions after parturition. Postweaning, offspring were maintained in ND/SED conditions for 18 wk. Results Maternal WD-induced increases in male offspring body mass was attenuated in the WD/RUN offspring (P

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