Peak Ventilation Reference Standards from Exercise Testing: From the FRIEND Registry

Purpose Cardiopulmonary exercise testing (CPX) provides valuable clinical information, including peak ventilation (VEpeak), which has been shown to have diagnostic and prognostic value in the assessment of patients with underlying pulmonary disease. This report provides reference standards for VEpeak derived from CPX on treadmills in apparently healthy individuals. Methods Nine laboratories in the United States experienced in CPX administration with established quality control procedures contributed to the Fitness Registry and the Importance of Exercise National Database from 2014 to 2017. Data from 5232 maximal exercise tests from men and women without cardiovascular or pulmonary disease were used to create percentiles of VEpeak for both men and women by decade between 20-79 years. Additionally, prediction equations were developed for VEpeak using descriptive information. Results VEpeak was found to be significantly different between men and women and across age groups (p

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