Anti-MAG neuropathy: role of IgM antibodies, the paranodal junction and juxtaparanodal potassium channels

Although the neuropathy associated with IgM antibodies against myelin-associated glycoprotein (MAG) has characteristic clinical, immunological and pathological features, there remains a gap in understanding the functional alterations underlying nerve dysfunction. Clinically, anti-MAG neuropathy is typically associated with a distal acquired demyelinating symmetric (DADS) phenotype characterised by a progressive predominantly sensory, distal neuropathy with distally accentuated conduction slowing seen on neurophysiology (Steck et al., 2006).

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