Increasing Vitamin D Serum Levels Is Associated with Reduced Pulmonary Exacerbations in Patients with Cystic Fibrosis

Context: In 2012, The North American CF Foundation published new guidelines for the treatment of vitamin D deficiency in individuals with CF. Objective: The objectives of our study were to assess the efficacy of these guidelines, and to test the effect of increasing vitamin D dosage on pulmonary function and exacerbations. Design: Pulmonary function tests and serum concentrations of 25-hydroxyvitamin D [25(OH)D] were measured one year prior to increasing vitamin D dosage according to the guidelines and at least one year later. In addition, days of hospitalization (DOH) and pulmonary exacerbations (PE) were counted and an average per year (DOHA and PEA, respectively) was calculated. Setting and Participants: 90 patients from The CF Clinic at Hadassah Mount-Scopus Hospital, Jerusalem, Israel. Results: The mean serum concentration of vitamin D increased significantly from 20.97 ng/ml (52.34 nmol/L) at baseline to 25.41 ng/ml (63.42 nmol/L) at the end of follow-up (p 

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