Publication date: Available online 16 November 2017
Source: Mutation Research/Reviews in Mutation Research
Author(s): Mats Ljungman, Luke Parks, Radhika Hulbatte, Karan Bedi
Abstract
Chromatin plays a critical role in organizing and protecting DNA. However, chromatin acts as an impediment for transcription and DNA repair. Histone modifications, such as H3K79 methylation, promote transcription and genomic stability by enhancing transcription elongation and by serving as landing sites for proteins involved in the DNA damage response. This review summarizes the current understanding of the role of H3K79 methylation in transcription, how it affects genome stability and opportunities to develop impactful therapeutic interventions for cancer.
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