The importance of appropriate control groups in perioperative analgesic studies: One size does not fit all

Postoperative pain remains poorly treated [1]. Specifically in the United States, opioids continue to be the main weapon used by clinicians to optimize postoperative analgesia [2]. Nonetheless, opioids can worsen patient reported quality of postoperative recovery [3,4]. In addition, the current national focus in the US to reduce the prescription of opioid analgesics and, subsequently, opioid diversion makes the use of multimodal analgesic strategies a very important topic in the perioperative care of surgical patients [5].

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