Somatosensory temporal discrimination in Parkinson’s disease, dystonia and essential tremor: pathophysiological and clinical implications

The somatosensory temporal discrimination threshold (STDT) measures a subject's ability to discriminate sensory stimuli in the temporal domain (Artieda et al. 1992; Conte et al. 2010; Tinazzi et al. 2013). Several studies have investigated the physiological mechanisms underlying the STDT in healthy subjects (Conte et al. 2012; Conte et al. 2017a; Lee et al. 2017; Leodori et al. 2017; Rocchi et al. 2016). Findings from neurophysiological studies based on transcranial magnetic stimulation suggest that the STDT strongly relies on inhibitory interneurons in the primary somatosensory cortex (S1) (Antelmi et al.

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