Progressive multiple sclerosis patients have a higher burden of autonomic dysfunction compared to relapsing remitting phenotype

Multiple sclerosis (MS) is an idiopathic demyelinating disorder of the central nervous system. It most commonly affects young individuals, between 20 and 40 years-of-age and represents the leading cause of non-traumatic neurologic disability in young adults (Edmonds et al., 2010). Although the exact etiology is unknown, there is a complex interaction between several environmental factors and a distinct genetic susceptibility which results in demyelinating lesions, the pathological hallmark of MS (Compston and Coles, 2008).

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