The transition to modernity and chronic disease: mismatch and natural selection

The transition to modernity and chronic disease: mismatch and natural selection

The transition to modernity and chronic disease: mismatch and natural selection, Published online: 09 May 2018; doi:10.1038/s41576-018-0012-3

The authors review the changes in life history traits brought forth by the Industrial Revolution and the evidence for antagonistic pleiotropic effects, whereby genetic variants associated with higher fitness in the past now predispose to diseases such as cancer and coronary artery disease.

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