Exercise Protects against Cancer-induced Cardiac Cachexia

Cancer has been shown to negatively stimulate autophagy, leading to a decline in cardiac function. Although exercise is cardioprotective, its influence over autophagy-mediated tumor growth and cardiac function are not well defined. Purpose This study aimed to determine the effect of exercise on tumor morphology and cardiac function. Methods Fisher 344 rats (n = 28) were assigned to one of four groups: 1) sedentary non-tumor bearing (SED), 2) sedentary tumor bearing (SED + T), 3) wheel run non-tumor bearing (WR), or 4) wheel run tumor bearing (WR + T). Rats remained sedentary or exercised for 6 wk. At week 4, rats in tumor groups were inoculated with MatBIII tumor cells. At week 6, cardiac function was measured. Results SED + T animals exhibited significantly lower left ventricular developed pressure when compared with SED, WR, and WR + T (P

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