Oscillatory local field potentials of the nucleus accumbens and the anterior limb of the internal capsule in heroin addicts

The nucleus accumbens (NAc), a crucial structure of the cortical-striatal-thalamic-cortical (CSTC) loop, is an important region in brain networks responsible for the motivational control of behavior (Robbins et al., 1996; Salamone et al., 2007; Nicola, 2010). Similar to the dorsal striatum, the NAc is characterized by the predominant expression of GABAergic medium spiny neurons (MSNs) and acts as the main structure of the ventral striatum (Mancall et al., 2014). Centrally situated in the CSTC loop, the NAc also receives numerous inputs from limbic regions, including the prefrontal cortex, the hippocampal formation, and the amygdala as well as the ventral tegmental area (VTA), which contains rich dopaminergic neurons (Everitt et al., 1999; Groenewegen et al., 1999; Yager et al., 2015).

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