MYOGENIC OXIDATIVE IMBALANCE INTERFERES WITH ANTRAL MOTILITY IN OBESE SUBJECTS

Obesity is characterized by a systemic low-grade chronic inflammatory oxidative condition that affects vascular and cardiac smooth muscle relaxation. In human antrum, relaxation is mediated by Vasoactive Intestinal Peptide (VIP) through cAMP and cGMP signalling pathways. A genome-wide association study has demonstrated an association between VIP and obesity.

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