Genetic Determinants for Leisure-Time Physical Activity

ABSTRACTPurposeLeisure-time physical activity (LTPA) is a well-established modifiable lifestyle determinant for multiple cardio-metabolic outcomes. However, current understanding of the genetic architecture that may determine LTPA remains very limited. Therefore, we aimed to examine the role of genetic factors in affecting LTPA, which has yet to be investigated comprehensively and in-depth.MethodsWe conducted a genome-wide analysis using 1000 Genomes Project imputed data from the Women's Health Initiative (n=11,865), the Jackson Heart Study (n=3,015) and the Framingham Heart Study (n=7,339). A series of secondary analyses, including candidate gene analysis, sequence kernel association tests, pathway analysis, functional annotation and expression quantitative trait loci analysis, were performed to follow up on the primary findings.ResultsEthnicity-specific genetic signals were investigated respectively for African Americans (AA) and European Americans (EA). Two variants, rs116550874 (meta-analysis: P = 1.63 × 10–7) and rs3792874 (meta-analysis: P = 8.33 × 10–7), were associated with LTPA in AA; rs28524846 (meta-analysis: P = 1.30 × 10–6) was identified for EA. We also replicated four previously reported loci (GABRG3, CYP19A1, PAPSS2 and CASR; P for lead SNPs

from Sports Medicine via xlomafota13 on Inoreader http://ift.tt/2Gs9e2W
via IFTTT