Acute Serum Cartilage Biomarker Response following Walking and Drop-Landing

ABSTRACTIntroductionAn in depth understanding of the healthy cartilage response to activities of daily living is needed to better understand the complex relationship between cartilage health and loading. The purpose was to assess the role of loading on the acute serum cartilage oligomeric matrix protein (COMP) response in recreationally active individuals.Methods40 individuals without previous lower extremity injury participated in this repeated measures study in which each participant completed all conditions during independent data collection sessions separated by at least one week. An antecubital blood draw was performed before and after walking, drop-landing, and control (i.e., sitting) conditions. Commercially available enzyme-linked immunosorbent assays measured COMP concentration. The acute COMP response was quantified as the percent change of COMP concentration from before to after each condition. A one-way, repeated measures ANOVA compared the acute COMP response between conditions. Post hoc Pearson product moment correlation and chi square analysis determined the relationship between the walking and drop-landing acute COMP response within individuals.ResultsAcute COMP response was greater following walking (+4.2, p=0.008) and drop-landing (+4.6%, p=0.002) compared to control (−2.3%), but did not differ between the walking and drop-landing conditions (p=0.596). The magnitudes of the acute COMP response during walking and drop-landing were correlated (r=0.56, p

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