Upregulation of calcium channel alpha-2-delta 1 subunit in dorsal horn contributes to spinal cord injury-induced tactile allodynia

Spinal cord injury (SCI) commonly results not only in motor paralysis but also in the emergence of neuropathic pain, both of which can impair the quality of life for SCI patients. In the clinical field, it is well known that pregabalin, which binds to the voltage-gated calcium channel α2δ-1subunit has therapeutic effects on neuropathic pain after SCI. A Previous study has demonstrated that SCI increased α2δ-1 in L4–6 dorsal spinal cord of SCI rats by Western blot analysis and that the increase of α2δ-1 was correlated with tactile allodynia of the hind paw.

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