The utility of motor unit number estimation methods versus quantitative motor unit potential analysis in diagnosis of ALS

Amyotrophic Lateral Sclerosis (ALS) is a fatal anterior horn cell disorder characterized by progressive degeneration of both upper and lower motor neurons (Brooks et al., 2000). Showing denervation activity by needle electromyography (EMG) and detection of chronic neurogenic changes are essential for ALS diagnosis. Motor unit potential (MUP) analysis is the most commonly used method to show chronic neurogenic changes. However, MUP analysis provides information about reinnervation rather than motor unit loss.

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