Runs of homozygosity: windows into population history and trait architecture

Runs of homozygosity: windows into population history and trait architecture

Runs of homozygosity: windows into population history and trait architecture, Published online: 15 January 2018; doi:10.1038/nrg.2017.109

Runs of homozygosity (ROH) are genomic regions of homozygosity where the identical maternal and paternal haplotypes are descended from a shared common ancestor, and they are well known to occur as a result of inbreeding. This article discusses strategies for detecting ROH, their underappreciated prevalence across diverse outbred populations and implications for complex traits and human disease.

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