Large genomic insertion at the Shh locus results in hammer toes through enhancer adoption [Genetics]

Enhancers are cis-regulatory elements which control the expression of genes in a defined spatiotemporal pattern, enabling the normal morphogenesis of organs and structures during embryogenesis. Enhancers control their target genes independently of their orientation or distance through chromosomal looping and are thought to evolve through various mutational mechanisms (1). A...

from Genetics via xlomafota13 on Inoreader http://ift.tt/2Eo4JFy
via IFTTT