Enhancer adoption caused by genomic insertion elicits interdigital Shh expression and syndactyly in mouse [Genetics]

Acquisition of new cis-regulatory elements (CREs) can cause alteration of developmental gene regulation and may introduce morphological novelty in evolution. Although structural variation in the genome generated by chromosomal rearrangement is one possible source of new CREs, only a few examples are known, except for cases of retrotransposition. In this...

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