EEG synchronization measures predict epilepsy-related BOLD-fMRI fluctuations better than commonly used univariate metrics

Because of their complementary properties, the simultaneous acquisition of the electroencephalogram (EEG) and blood-oxygen-level-dependent (BOLD) functional magnetic resonance imaging (fMRI) has been actively pursued. This is particularly important in the field of epilepsy, motivated by the need to map epileptic activity, as accurately as possible, in the brain of patients with drug-resistant focal epilepsy undergoing pre-surgical evaluation (Hoffmann et al., 2000; Ives et al., 1993; Lemieux et al., 2001; LeVan and Gotman, 2009; Salek-Haddadi et al., 2006).

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